Exercise physiology and human performance: systems biology before systems biology!
نویسندگان
چکیده
منابع مشابه
Fatigue mechanisms determining exercise performance: integrative physiology is systems biology.
FOR MORE THAN A CENTURY, applied physiologists have investigated the complex nature of fatigue and its implications for exercise performance. Long before the term “systems biology” entered the biomedical lexicon, physiologists appreciated the need to understand fatigue at various levels of integration and across multiple organ systems, a point eloquently highlighted in a recent editorial (13). ...
متن کاملIntegrated physiology and systems biology of PPARα
The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription factor that plays a major role in metabolic regulation. This review addresses the functional role of PPARα in intermediary metabolism and provides a detailed overview of metabolic genes targeted by PPARα, with a focus on liver. A distinction is made between the impact of PPARα on metabolism upon physiological, pharm...
متن کاملPhysiology and genomics: toward systems biology.
The last ten years have seen an unprecedented merge of physiology and genomics. While the field of physiological genomics is still very young, the introduction of the concept of systems biology promises to propel physiological genomics to a whole new level. In this brief article, we outlined some of the great opportunities and challenges for physiologists at this exciting time of physiological ...
متن کاملSystems biology and the biology of systems.
When I sit down to write an editorial for Physiology, I flatter myself that the two or three people who will ultimately read it want to hear my thoughts on a “big” topic. It strikes me that, within the rarefied realm of academic biology, there few bigger topics, or at least few topics more all encompassing in their scope, than Systems Biology. Perhaps it is the ambiguity inherent in its name th...
متن کاملIntegrative biology and systems biology
Demarcations of scientific fields have always followed either a conceptual breakthrough or have been a result of profoundly enabling technologies. Quantum theory and quantum mechanics revolutionized physics and engineering, but highenergy physics is a discipline fundamentally enabled by the linear accelerator. Similarly, the discovery of the structure of DNA gave birth to molecular biology; str...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2008
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2007.148411